Research Articles

Beneficial impact of garlic supplements. Huge contribution to the growth of the immune system

G arlic has been described as containing phytonutrients with healthy properties. In this article, the effect of a bioactive garlic food supplement intake on human plasma metabolome was examined for the purpose of researching the beneficial action on the human organism. With this purpose, a dietary intervention assay was performed in thirty healthy volunteers collecting plasma samples before intake and after one month of daily supplement consumption.

These results are according with the antioxidant and antiglycation properties.

"A fingerprinting metabolomic approach reveals deregulation of endogenous metabolites after the intake of a bioactive garlic supplement"

Álvaro Fernández-Ochoaa,b , Isabel Borrás-Linaresa,⁎ , Alberto Bañosc , J. David García-Lópezc , Enrique Guillamónc , Cristina Nuñez-Lechadoc , Rosa Quirantes-Pinéa , Antonio Segura-Carreteroa

Effects of zinc salts on the respiratory system

Respiratory syncytial virus (RSV) is the most important viral cause of acute infection of the respiratory tract (IRA) in childhood, with its increased morbidity in infants.
This article presents the importance of zinc supplementation to decrease the morbidity of lower respiratory tract infection in pediatric patients. Zinc ions were also found to inhibit replication in this study in vitro of viruses such as rhinovirus, HSV, HIV and vaccinia virus.

"Effect of Zinc Salts on Respiratory Syncytial Virus Replication"

Rahaman O. Suara and James E. Crowe, Jr.

Modulation of the immune response in inflammatory processes

Researchers from the Department of Pharmacology at the University of Granada have shown that the active ingredients present in AlioCare are capable of modulating the immune response in models of Crohn’s disease and ulcerative colitis, restoring intestinal epithelium and improving inflammation parameters and homeostasis of intestinal microbiome.

"The Immunomodulatory Properties of Propyl-Propane Thiosulfonate Contribute to its Intestinal Anti-Inflammatory Effect in Experimental Colitis."

Vezza T., Algieri F., Garrido-Mesa J., Utrilla MP., Rodríguez-Cabezas ME., Baños A., Guillamón E., García F., Rodríguez-Nogales A., Gálvez J..

Broad spectrum antimicrobial

This study by researchers from the Virgen de las Nieves Hospital and the Department of Microbiology of the University of Granada demonstrates the important antimicrobial activity of the compounds present in AlioCare in the face of a wide variety of bacteria that are multidrug resistant to antibiotics.

"In Vitro Antibacterial Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate Derived from Allium spp. against Gram-Negative and Gram-Positive Multidrug-Resistant Bacteria Isolated from Human Samples."

Sorlozano-Puerto A., Albertuz-Crespo M., Lopez-Machado I., Ariza-Romero JJ., Baños-Arjona A., Exposito-Ruiz M., Gutierrez-Fernandez J

Evidence-Based Complimentary and Alternative Medicine

In this study the researchers concluding, by maintaining the immune defense system within a normal healthy state lowers the incidence of infection and/or lessens the severity of symptoms and/or shortens the duration of common colds. The intakes of some nutrients, botanicals and the products like Aliocare can significantly influence several components of immunity.

"Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds—Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds"

Mariangela Rondanelli, 1 Alessandra Miccono, 1 Silvia Lamburghini, 1 Ilaria Avanzato, 1 Antonella Riva, 2 Pietro Allegrini, 2 Milena Anna Faliva, 1 Gabriella Peroni, 1 Mara Nichetti, 1 and Simone Perna 1

Optimised nutrition and a healthy immune system in the fight against viral infections

Balanced nutrition, which provides all the essential nutrients we need, is important to support an effective immune function. This is particularly relevant with the current situation regarding the spread of coronavirus infections; the immune system is the body’s first line of defence. A well-functioning immune system helps to reduce the risk of viral infections, its duration and severity. Several vitamins and minerals play an important and complementary role in supporting the immune system like Aliocare.

"In light of the ongoing coronavirus outbreak, Dr Manfred Eggersdorfer, Professor for Healthy Ageing at the University Medical Center Groningen, talks to Dr Kevin Robinson about the role that micronutrients and omega-3 fatty acids can play to support the immune response, particularly with respect to respiratory virus infections."

Professor Manfred Eggersdorfer, Dr Kevin Robinson

A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection.

Daily micronutrient intake like Aliocare is necessary to support immune function may be higher than current recommended dietary allowances.

"Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, which play vital, often synergistic roles at every stage of the immune response."

Gombart AF1, Pierre A2, Maggini S2

Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil

Eighteen active substances, including 17 organosulfur compounds found in garlic essential oil (T), were identified by GC–MS analysis. For the first time, using the molecular docking technique.

"The results show that the 17 organosulfur compounds, accounting for 99.4% contents of the garlic essential oil, have strong interactions with the amino acids of the ACE2 protein and the main protease PDB6LU7 of SARS-CoV-2. The strongest anticoronavirus activity is expressed in allyl disulfide and allyl trisulfide, which account for the highest content in the garlic essential oil (51.3%). Interestingly, docking results indicate the synergistic interactions of the 17 substances, which exhibit good inhibition of the ACE2 and PDB6LU7 proteins. The results suggest that the garlic essential oil is a valuable natural antivirus source, which contributes to preventing the invasion of coronavirus into the human body."

Bui Thi Phuong Thuy, Tran Thi Ai My, Nguyen Thi Thanh Hai, Le Trung Hieu, Tran Thai Hoa, Huynh Thi Phuong Loan, Nguyen Thanh Triet, Tran Thi Van Anh, Phan Tu Quy, Pham Van Tat, Nguyen Van Hue, Duong Tuan Quang, Nguyen Tien Trung, Vo Thanh Tung, Lam K. Huynh, and Nguyen Thi Ai Nhung

Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking

The complex phytochemistry of garlic (Allium sativum) has often been studied. And the present research may provide some meaningful guidance for the prevention and treatment of SARS-CoV-2.

"The lack of effective anti-SARS-CoV-2 agents is a current problem and there is urgent demand to discover anti-SARS-CoV-2 inhibitors to combat this deadly disease. SARS-CoV-2 Mpro is an important target for the design of therapeutically useful drugs. In the present study, alliin was screened out to dock with SARS-CoV-2 Mpro and the mechanisms of alliin and known inhibitors were investigated. The results suggested that alliin may be a good candidate for the prevention and treatment of SARS-CoV-2."

Bijun Cheng & Tianjiao Li
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